The concentration of low‐density lipoprotein (LDL) cholesterol (C) in plasma is a key determinant of cardiovascular disease risk and human genetic studies have long endeavoured to elucidate the pathways that regulate LDL metabolism. Massive genome‐wide association studies (GWASs) of common genetic variation associated with LDL‐C in the population have implicated SORT1 in LDL metabolism. Using experimental paradigms and standards appropriate for understanding the mechanisms by which common variants alter phenotypic expression, three recent publications have presented divergent and even contradictory findings. (...) Interestingly, although these reports each linked SORT1 to LDL metabolism, they did not agree on a mechanism to explain the association. Here, we review recent mechanistic studies of SORT1 – the first gene identified by GWAS as a determinant of plasma LDL‐C to be evaluated mechanistically. (shrink)

Researchers are beginning to transition from studying human–automation interaction to human–autonomy teaming. This distinction has been highlighted in recent literature, and theoretical reasons why the psychological experience of humans interacting with autonomy may vary and affect subsequent collaboration outcomes are beginning to emerge (de Visser et al., 2018;Wynne and Lyons, 2018). In this review, we do a deep dive into human–autonomy teams (HATs) by explaining the differences between automation and autonomy and by reviewing the domain of human–human teaming to make (...) inferences for HATs. We examine the domain of human–human teaming to extrapolate a few core factors that could have relevance for HATs. Notably, these factors involve critical social elements within teams that are central (as argued in this review) for HATs. We conclude by highlighting some research gaps that researchers should strive toward answering, which will ultimately facilitate a more nuanced and complete understanding of HATs in a variety of real-world contexts. (shrink)

Functional localization is a central aim of cognitive neuroscience. But the nature and extent of functional localization in the human brain have been subjects of fierce theoretical debate since the 19th Century. In this essay, I first examine how concepts of functional localization have changed over time. I then analyze contemporary challenges to functional localization drawing from research on neural reuse, neural degeneracy, and the context-dependence of neural functions. I explore the consequences of these challenges for topics in philosophy of (...) science and philosophy of mind including localizationist versus anti-localizationist approaches to cognitive neuroscience, multiple realizability, reverse inference in functional neuroimaging, and the modularity of mind. (shrink)

Multifunctionality poses significant challenges for human brain mapping. Cathy Price and Karl Friston argue that brain regions perform many functions in one sense and a single function in another. Thus, neuroscientists must revise their “cognitive ontologies” to obtain systematic mappings. Colin Klein draws a different lesson from these findings: neuroscientists should abandon systematic mappings for context-sensitive ones. I claim that neither account succeeds as a general treatment of multifunctionality. I argue that brain areas, like genes or organs, are multifunctional in (...) different ways. I call this the “functional heterogeneity hypothesis.” I contend that different multifunctional parts require different mapping strategies. (shrink)

This important collection of essays is a synthesis of foundational studies in Bayesian decision theory and statistics. An overarching topic of the collection is understanding how the norms for Bayesian decision making should apply in settings with more than one rational decision maker and then tracing out some of the consequences of this turn for Bayesian statistics. There are four principal themes to the collection: cooperative, non-sequential decisions; the representation and measurement of 'partially ordered' preferences; non-cooperative, sequential decisions; and pooling (...) rules and Bayesian dynamics for sets of probabilities. The volume will be particularly valuable to philosophers concerned with decision theory, probability, and statistics, statisticians, mathematicians, and economists. (shrink)

Prior research has demonstrated that trust in robots and performance of robots are two important factors that influence human–autonomy teaming. However, other factors may influence users’ perceptions and use of autonomous systems, such as perceived intent of robots and decision authority of the robots. The current study experimentally examined participants’ trust in an autonomous security robot (ASR), perceived trustworthiness of the ASR, and desire to use an ASR that varied in levels of decision authority and benevolence. Participants (N = 340) (...) were recruited from Amazon Mechanical Turk. Results revealed the participants had increased trust in the ASR when the robot was described as having benevolent intent compared to self-protective intent. There were several interactions between decision authority and intent when predicting the trust process, showing that intent may matter the most when the robot has discretion on executing that intent. Participants stated a desire to use the ASR in a military context compared to a public context. Implications for this research demonstrate that as robots become more prevalent in jobs paired with humans, factors such as transparency provided for the robot's intent and its decision authority will influence users’ trust and trustworthiness. (shrink)

Machine generated contents note: Contributors ix -- Foreword by Douglas A. Boyd andJoseph D. Straubhaar xiii -- Preface byMariaHenson xv -- Acknowledgments xvii -- Part I. Introduction 1 -- Chapter 1. Journalism as a Mission: Ethics and Purpose -- from an International Perspective -- by Joseph B. Atkins 3 -- Chapter 2. Chaos and Order: Sacrificing the Individual for the -- Sake of Social Harmony -- by John C. Merrill 17 -- Part II. In the United States and Latin (...) America 37 -- Chapter 3. Ways of a Muckraker -- by Jerry Mitchell 39 -- Chapter 4. A Sinister Zone of Likeness: Journalists as Heroes and -- Villains in the U.S. South and in Central and Eastern -- Europe -- by Joseph B. Atkins 45 -- Chapter 5. From Collusion to Independence: The Press, The Ruling -- Party, and Democratization in Mexico -- byMichaelSnodgrass 55 -- Chapter 6. The Outspoken Journalist Is an Expression, a Symbol -- of Colombia -- by Stephen E Jackson 69 -- Part III. In Europe 77 -- Chapter 7. The Stranger: Minorities and Their Treatment -- in the German Media -- by Georg Ruhrmann 79 -- Chapter 8. Between State Control and the Bottom Line: -- Journalism and Journalism Ethics in Hungary -- by Ildiko Kaposi and Eva Vajda 91 -- Chapter 9. SITA: Slovakia's First Independent News Service and -- Its Battles with the Huey Long of the Danube -- byPavol Mudry 101 -- Chapter 10. Holding Politicians' Feet to the Fire in Slovenia -- by Bernard Nezmah 111 -- Part IV. In the Middle East and Africa 121 -- Chapter 11. Lebanese Television: Caught Between the -- Government and the Private Sector -- by Nabil Dajani 123 -- Chapter 12. Press Freedom and the Crisis of Ethical Journalism -- in Southern Africa -- by Regina Jere-Malanda 143 -- Chapter 13. Nigerian Press Ethics and the Politics of Pluralism -- by Minabere Ibelema 153 -- Part V. In South and East Asia 169 -- Chapter 14. The Indian Press: Covering an Enigma -- byJayanti Ram-Chandran 171 -- Chapter 15. Palace Intrigue in Katmandu and the Press in Nepal -- byAkhilesh Upadhyay 181 -- Chapter 16. The Press in Japan: Job Security versus -- Journalistic Mission -- by Takehiko Nomura 187 -- Part VI. Three Journalists and Their Missions 201 -- Chapter 17. A Journey in Journalism: From Idealism -- to Bankruptcy -- by Neil White III 203 -- Chapter 18. Reclaiming Responsibility: A Journalist and Artist -- in the Catholic Worker Movement -- by Chuck Trapkus 211 -- Chapter 19. Ryszard Kapuscinski: The Empathetic Existentialist -- by Joseph B. Atkins and Bernard Nezmah 217 -- Postscript The White Rose: On the Martyrdom of Student Pamphleteers in -- Nazi Germany and Their Legacy -- by Joseph B. Atkins 227 -- References 233 -- Index 243. (shrink)

The standard “gladiatorial” interpretation of the Modes of Agrippa has undergone several recent attacks. Scholars have criticized it because it seems to portray the skeptic as a dogmatist about logical support and because it does not treat all five Modes as part of the system. Although some have attempted to patch up the standard interpretation to address these issues, I raise a further problem: The gladiatorial interpretation cannot make sense of the skeptic using the Modes on herself, to suspend her (...) own judgment. In light of these problems, I propose a fresh interpretation: The Agrippan Modes should be understood, not as arguments (or argument forms), but as types of dialectical challenge that the skeptic can use in an endless inquiry into any dogmatic position. (shrink)

When can a Bayesian investigator select an hypothesis H and design an experiment to make certain that, given the experimental outcome, the posterior probability of H will be lower than its prior probability? We report an elementary result which establishes sufficient conditions under which this reasoning to a foregone conclusion cannot occur. Through an example, we discuss how this result extends to the perspective of an onlooker who agrees with the investigator about the statistical model for the data but who (...) holds a different prior probability for the statistical parameters of that model. We consider, specifically, one-sided and two-sided statistical hypotheses involving i.i.d. Normal data with conjugate priors. In a concluding section, using an "improper" prior, we illustrate how the preceding results depend upon the assumption that probability is countably additive. (shrink)

Pyrrhonian skeptics, according to Sextus Empiricus, suspend judgment in the face of equally strong oppositions, but they also continue to investigate. This joint characterization has puzzled scholars: Why keep investigating if the evidence demands epochē? On this point, Sextus has been accused of muddled thinking at best and incoherence at worst. In this paper, I explain how investigative activity harmonizes with the suspensive mindset. My interpretation helps to explain several puzzling features of Pyrrhonian philosophy in addition to the idea that (...) one can both suspend judgment and continue investigating. (shrink)

First published in 1881, as part of the Pitt Press Series, this book presents a guide to classical philosophy aimed at undergraduates and those studying the works of Cicero, Plato or Aristotle. All quotations are in the original Greek and Latin. This book will be of value to anyone with an interest in the history of philosophy and perspectives on classical thought.

What does cognitive neuroscience contribute to our philosophical understanding of concepts? Over the past several decades, brain researchers have employed the tools of cognitive neuroscience and neuropsychology to probe the structure and func­tion of the conceptual system. The results of this effort, which are often extremely surprising, raise more questions than they resolve. Brain research has invigorated age-old philosophical debates about the nature of concepts—such as whether concepts are perceptual representations—and generated new controversies about how conceptual knowledge is organized. In (...) this essay, I examine three debates in the neuroscience of conceptual knowledge: whether concepts are embodied or couched in amodal representations, whether conceptual knowledge is organized according to evolved categories, and whether the brain has multiple conceptual systems. My purpose is not to resolve these debates—rather, I intend to show how many of the proposed solutions fail to accommodate the diverse range of data emerging from cognitive neuroscience. I am therefore skeptical that brain data alone will resolve these issues, but remain optimistic that neuroscience has much to contribute to philosophical accounts of concepts. (shrink)

Of Goals and Goods and Floundering About: A Dissensus Report on Clinical Ethics Consultation Content Type Journal Article Pages 275-291 DOI 10.1007/s10730-009-9101-1 Authors Jeffrey P. Bishop, Vanderbilt University Center for Biomedical Ethics and Society 2525 West End Avenue, Suite 400 Nashville Tennessee 37203 USA Joseph B. Fanning, Vanderbilt University Center for Biomedical Ethics and Society 2525 West End Avenue, Suite 400 Nashville Tennessee 37203 USA Mark J. Bliton, Vanderbilt University Center for Biomedical Ethics and Society 2525 West End Avenue, (...) Suite 400 Nashville Tennessee 37203 USA Journal HEC Forum Online ISSN 1572-8498 Print ISSN 0956-2737 Journal Volume Volume 21 Journal Issue Volume 21, Number 3. (shrink)

When can a Bayesian investigator select an hypothesis H and design an experiment (or a sequence of experiments) to make certain that, given the experimental outcome(s), the posterior probability of H will be lower than its prior probability? We report an elementary result which establishes sufficient conditions under which this reasoning to a foregone conclusion cannot occur. Through an example, we discuss how this result extends to the perspective of an onlooker who agrees with the investigator about the statistical model (...) for the data but who holds a different prior probability for the statistical parameters of that model. We consider, specifically, one-sided and two-sided statistical hypotheses involving i.i.d. Normal data with conjugate priors. In a concluding section, using an "improper" prior, we illustrate how the preceding results depend upon the assumption that probability is countably additive. (shrink)

For almost a decade, I have taught an undergraduate course on death and dying and have served as an ethics consultant in an academic medical center where I support patients and families navigating difficult end-of-life decisions. Chapters from Elisabeth Kübler-Ross's On Death and Dying, Sherwin Nuland's How We Die, and Atul Gawande's Being Mortal are required reading in my course because these physician-writers offer detailed, firsthand stories that help readers imagine the places and faces of dying patients and their families. (...) Respectively, these authors teach us about patients' changing perceptions about their own deaths, the physio-cultural shapes of the dying process, and the fraught... (shrink)

This book provides an elaboration and evaluation of the dominant conceptions of genetic counseling as they are accounted for in three different models: the teaching model; the psychotherapeutic model; and the responsibility model. The elaboration of these models involves an identification of the larger traditions, visions and theories of communication that underwrite them; the evaluation entails an assessment of each model’s theses and ultimately a comparison of their adequacy in response to two important concerns in genetic counseling: the contested values (...) of non-directiveness and the recognition of differences across perspectives, with special focus on how religious and spiritual beliefs of patients are coordinated with the networks of meaning in genetics. Several insights are made explicit in this project through the work of Robert Brandom. Brandom’s deontic scorekeeping model demonstrates how dialogue is at the root of grasping a conceptual content. Against this backdrop, professional communications such as genetic counseling can be seen as late developments in linguistic practices that have structural challenges. Brandom’s model reminds us that the professional needs the client’s understanding to grasp conceptual content in a particular context. (shrink)

Ever since the publication of Placide Tempel's epoch-making work Bantu Philosophy, African philosophers have worked to dispel the myth that there is no metaphysics in Africa.

Prior research has demonstrated that trust in robots and performance of robots are two important factors that influence human–autonomy teaming. However, other factors may influence users’ perceptions and use of autonomous systems, such as perceived intent of robots and decision authority of the robots. The current study experimentally examined participants’ trust in an autonomous security robot (ASR), perceived trustworthiness of the ASR, and desire to use an ASR that varied in levels of decision authority and benevolence. Participants (N = 340) (...) were recruited from Amazon Mechanical Turk. Results revealed the participants had increased trust in the ASR when the robot was described as having benevolent intent compared to self-protective intent. There were several interactions between decision authority and intent when predicting the trust process, showing that intent may matter the most when the robot has discretion on executing that intent. Participants stated a desire to use the ASR in a military context compared to a public context. Implications for this research demonstrate that as robots become more prevalent in jobs paired with humans, factors such as transparency provided for the robot's intent and its decision authority will influence users’ trust and trustworthiness. (shrink)

SummaryUtah has the highest total fertility of any state in the United States and also the highest proportion of population affiliated with the Church of Jesus Christ of Latter-day Saints. Data were used from the 1996 Utah Health Status Survey to investigate how annual household income, education and affiliation with the LDS Church affect fertility for married women in Utah. Younger age and higher education were negatively correlated with fertility in the sample as a whole and among non-LDS respondents. Income (...) was negatively associated with fertility among non-LDS respondents. However, income was positively correlated with fertility among LDS respondents. This association persisted when instrumental variables were used to address the potential simultaneous equations bias arising from the potential endogeneity of income and fertility. The LDS religion's pronatalist stance probably encourages childbearing among those with higher income. (shrink)

Erratum to: Echo Calling Narcissus: What Exceeds the Gaze of Clinical Ethics Consultation? Content Type Journal Article Pages 171-171 DOI 10.1007/s10730-010-9132-7 Authors Jeffrey P. Bishop, Saint Louis University Tenet Chair of Health Care Ethics, Albert Gnaegi Center for Health Care Ethics Salus Center, Room 527, 3545 Lafayette Ave St. Louis MO 63104-1314 USA Joseph B. Fanning, Vanderbilt University Center for Biomedical Ethics and Society 2525 West End Ave., 4th Floor, Suite 400 Nashville TN 37203 USA Mark J. Bliton, Vanderbilt (...) University Center for Biomedical Ethics and Society 2525 West End Ave., 4th Floor, Suite 400 Nashville TN 37203 USA Journal HEC Forum Online ISSN 1572-8498 Print ISSN 0956-2737 Journal Volume Volume 22 Journal Issue Volume 22, Number 2. (shrink)